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Scientist Kate Adamala doesn’t remember exactly when she realized her lab at the University of Minnesota was working on something potentially dangerous — so dangerous in fact that some researchers think it could pose an existential risk to all life forms on Earth.

She was one of four researchers awarded a $4 million US National Science Foundation grant in 2019 to investigate whether it’s possible to produce a mirror cell, in which the structure of all of its component biomolecules is the reverse of what’s found in normal cells.

The work was important, they thought, because such reversed cells, which have never existed in nature, could shed light on the origins of life and make it easier to create molecules with therapeutic value, potentially tackling significant medical challenges such as infectious disease and superbugs. But doubt crept in.

“It was never one light bulb moment. It was kind of a slow boiling over a few months,” Adamala, a synthetic biologist, said. People started asking questions, she added, “and we thought we can answer them, and then we realized we cannot.”

The questions hinged on what would happen if scientists succeeded in making a “mirror organism” such as a bacterium from molecules that are the mirror images of their natural forms. Could it inadvertently spread unchecked in the body or an environment, posing grave risks to human health and dire consequences for the planet? Or would it merely fizzle out and harmlessly disappear without a trace?

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09 Nov 2025 - 07:32 pm

Voters up and down the East Coast delivered Democrats a sweep on Tuesday, electing candidates across the party’s ideological spectrum in a vivid show of discontent with President Donald Trump nearly a year into his second term.
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In Virginia, moderate former Rep. Abigail Spanberger turned in the strongest Democratic performance in the state’s recent history as she coasted to victory. And in New Jersey, another moderate, Rep. Mikie Sherrill, busted apart the coalition Trump and her Republican rival, former state lawmaker Jack Ciattarelli, had put together to close the Garden State’s gap in recent elections.
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In New York City, democratic socialist Zohran Mamdani’s win marked the second time this year he’d defeated former Gov. Andrew Cuomo — first in the Democratic primary, and then in the general election, with Cuomo running as an independent backed by Trump.
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The Democratic wins by candidates with sharp ideological differences will do little to settle the party’s long-raging internal debate about its way forward, with a host of competitive midterm primaries just months away and the 2028 presidential primary already looming.

But their campaigns had some things in common. Though their solutions were different, the candidates focused on the issue of affordability. And they were all fiercely critical of Trump’s performance.

“It’s not just a message about Democrats; it’s a message about our entire country. I think Americans are appalled by what they are seeing coming out of this administration,” New York Rep. Alexandria Ocasio-Cortez said on CNN from Mamdani’s victory party.

In California, voters approved by a wide margin a redistricting ballot measure intended to boost Democrats’ chances in next year’s battle for control of the House. And in Pennsylvania, Democratic state Supreme Court justices won their retention votes, allowing Democrats to keep their majority on the high court in a perennial battleground state where legal challenges over voting rules are all but certain.
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